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KMID : 0360319950270010001
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 1 p.1 ~ p.7
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Natural Killer(NK) Cell Cytotoxicity According to the Expression of c-er-B-2 Protein in Human Gastric Cancer Cells
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박병우
심강섭/노성훈/김충배/이경식
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Abstract
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Although there is still controversy to the relationship between c-erbB-2 protein expression and prognosis of the gastric carcinoma, there were many reports about the poor prognosis with the expression of c-erbB-2 in gastric carcinoma.
The mechanisms underlying this phenomenon are not known. However several possibilities such as acquired resistance to 5-Fluorouracil(5-FU) and resistance to the host immune system were suggested.
So we performed this study to evaluate whether c-erbB-2 expression can alter the natural killer(NK)cell cytotoxic activity.
Using single cell suspensions from primary gastric cancer tissues and malignant ascites due to stomach cancer, the immunohistochemical reactivity to c-cerB-2 protein was examined and we performed the tests for NK cell cytotoxic activity.
The c-erbB-2(+) cancer cells were significantly more resistant to NK cell cytotoxic activity than c-erbB-2(-) cancer cells. However there was no significant difference in the resistance to Nk cell cytotoxic activity according to their
immunohistochemical staining intensities.
These results suggest that the resistance to the NK cell cytotoxicity may be one of the possible mechanisms of the poorer prognosis of the c-erbB-2(+)gastric cancers.
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